Botox May Have a New Use: Treating Depression

December 14, 2016 | Beth Stebner

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Sure, Botox can help get rid of your frown lines. But can it treat the reason why you’re frowning in the first place?

Science is tantalizingly close, at least according to Jason S. Reichenberg, MD, director of dermatology at the University of Texas-Austin and co-author of a study about the correlation between Botox and depression that was just published in the Journal of the American Academy of Dermatology.Read More

Treatment of depression with Botox: A randomized, double-blind, placebo controlled trial | Journal of Psychiatric Research

Journal of Psychiatric Research | Eric Finzi a,*, Norman E. Rosenthal b,c

a Chevy Chase Cosmetic Center, Chevy Chase, MD 20815, USA
b Capital Clinical Research Associates, Rockville, MD 20852, USA
c Georgetown Medical School, Washington, DC 20057, USA

"Converging lines of evidence suggest a role for facial expressions in the pathophysiology and treatment of mood disorders. To determine the antidepressant effect of onabotulinumtoxinA (OBA) treatment of corrugator and procerus muscles in people with major depressive disorder, we conducted a double blind, randomized, placebo-controlled trial. In an outpatient clinical research center, eighty-five subjects with DSM-IV major depression were randomized to receive either OBA (29 units for females and 40 units for males) or saline injections into corrugator and procerus frown muscles (74 subjects were entered into the analysis). Subjects were rated at screening, and 3 and 6 weeks after OBA treatment. The primary outcome measure was the response rate, as defined by 50% decrease in score on the MontgomeryeAsberg Depression Rating Scale (MADRS). Response rates at 6 weeks from the date of injection were 52% and 15% in the OBA and placebo groups, respectively (Chi-Square (1) 1⁄4 11.2, p < 0.001, Fisher p < 0.001). The secondary outcome measure of remission rate (MADRS score of 10 or less) was 27% with OBA and 7% with placebo (Chi-square (1) 1⁄4 5.1, p < 0.02, Fisher p < 0.03). Six weeks after a single treatment, MADRS scores of subjects were reduced on average by 47% in those given OBA, and by 21% in those given placebo (ManneWhitney U, p < 0.0005). In conclusion, a single treatment with OBA to the corrugator and procerus muscles appears to induce a significant and sustained antidepressant effect in patients with major depression. Trial Registration: Identifier: NCT01556971." Read More

How Botox Became the Drug That's Treating Everything: Time Magazine

January 16, 2017 | Alexandra Sifferlin

"Ironically, it’s the off-target effects of Botox that have some researchers most excited. Botox may be working in a way that is different from what we think. It may be even more complex.’ EWA BOMBA-WARCZAK, University of Wisconsin–Madison Read More

Botox is the New Make-up: Time Magazine


June 19, 2015 | Amanda Elliott

“Talk to me when you’re 30,” my friend said, insinuating that I will join the growing fad and get some Botox when wrinkles start to show and my face becomes far from pretty...Since it is National Martini Day, while you raise your martini and get together for girl’s night this Friday, add this to your cocktail chatter—Time Magazine just published  a piece, “Nip. Tuck. Or Else,” stating that cosmetic surgery is on the rise. More precisely, Americans have had 3.5 million rounds of Botox. THIS YEAR...Let’s face it, we do A LOT to meet beauty standards sans syringe. We wear make-up, apply umpteen creams to our face daily, and schedule the weekly maini/pedi. Add this to your beauty regimen." Read More

Depressed? Botox might be the key to happiness


May 4, 2015 | Julie Revelant

"Picture this: your appointment with your therapist is coming to a close and instead of writing you a prescription for an antidepressant, he gives you an injection of Botox and sends you on your way. This, experts say, could be the future of treatment for depression. Currently used off-label for depression, Botox is in phase 2 clinical trials for FDA approval. “Once it becomes FDA-approved, hopefully we will have mental health professionals using it,” said Dr. Eric Finzi, a board-certified dermasurgeon in the Washington, D.C. metro area who pioneered the treatment and trains psychiatrists to use it." Read More

Injection Offers Option to Slim Down Double Chin Without Surgery


April 30, 2015 | Catherine Saint Louis

NEW YORK TIMES- "...The Food and Drug Administration on Wednesday approved the injection, called Kybella, for the reduction of moderate to severe fat deposits under the chin. The active ingredient, deoxycholic acid, dissolves fat, permitting dermatologists and plastic surgeons to resculpt the chin area without surgery.

“For highly selected patients who have under-chin fat without sagging skin, this will work,” said Dr. Rod J. Rohrich, a professor of plastic surgery at the University of Texas Southwestern Medical Center in Dallas. He was not involved in the clinical trials.

Dr. Rohrich, editor in chief of the journal Plastic and Reconstructive Surgery, predicted that both men and women would want the procedure. “So many consumers don’t want a knife; they want a needle,” he said." Read More

Meet the Women who are Getting ‘Breakup Botox’


December 27, 2014 | Alyssa Shelasky

NEW YORK POST - "...And it’s not only for superficial reasons. More women (and some men) are turning to the baby-face needle to feel better after suffering heartbreak… "The way Botox plays with mood is being much more recognized, scientifically, and I think it's valid," [Dr. Chapas] explains. "Frowning signals your brain that you're sad or depressed. If you can't make that frown, your body doesn't pick up on those cues, and it thinks that your mood is better." Read More

Botox isn't just for Women: Why so many men are 'Bro-tox' Obsessed


November 4, 2014 | Emily Jane Fox

NEW YORK (CNNMoney) - "For years, the popularity of Botox has spread from the wrinkle-free foreheads of celebrities to socialites to soccer moms. But now, more men than ever are flocking to the injectable line-filler, hoping 'Bro-tox' will knock a few years off of their appearance. More than 385,000 men in the U.S. got Botox injections last year, according to the American Society of Plastic Surgeons. That's a 310 percent increase from a decade ago." Read More

More Evidence BOTOX® Cosmetic Works for Depression


June 19, 2014 | Caroline Cassels

"A single injection of Botox®, which is typically used to improve the appearance of facial wrinkles, may be an effective treatment for depression...According to the investigators, positive effects on mood have been seen in patients who've had Botox® treatment for the frown lines in the area above the nose and between the eyebrows." Read More

Washington's Secret To Staying Relevant


July 13th 2014 | Roxanne Roberts

"We’re not talking about the enormous breasts and paralyzed faces of Hollywood, or the frozen, wind-tunnel look of New York socialites. D.C. is all about refined, subtle improvements: an unlined face on HD television, a healthy glow in the conference room." Read more

Face the Facts

Nov 16th 2013

"An appreciation of what is “beautiful”, moreover, seems innate—as Dr Elia’s hypothesis requires it should be. Babies a few days old prefer pictures of the faces of people whom their elders would define as beautiful to those they would not, regardless of the sex and race of either the baby or the person in the photo." Read more